Is fibromyalgia a “mice infestation”?

mice infestation

Is Fibromyalgia a “mice infestation”?

My “perplexing findings” so far…

 My first perplexing finding: NO palpation skills

Since I started the study of the intriguing “back mice” (palpable subcutaneous nodules due to a circumscribed congested inter-fascial fibro-fatty tissue tension), I have palpated many lumbar nodules, sometimes painless sometimes extremely painful. Sometimes single sometimes multiple, unilateral or bilateral. I have shown how to palpate them to many of the doctors around me that have shown interest about it. But I am still perplexed that before the summer of 2017 I was so unaware of the ”back mice” existence because these lumbar nodules are a frequent lumbar finding when you search for it properly. And I am still perplexed that so many doctors, even if I explain them, do not palpate these “intriguing nodules”.

Then how come the medical community is so unaware of their existence? I have noticed how little palpating skills my colleagues and me had and how little I was taught about palpation at the medical university. We were trained to study, to memorize, and to learn strange syndromes of many rare diseases; we had to know the management of complicated patients or incredible surgical techniques. We were not trained to explore properly with our hands patients affected with the so called “chronic musculoskeletal pain syndromes”. Somehow the message was “Why bother? Just give them painkillers. They will not die from it…. The hands were not important, just the diagnoses by imaging, the X-rays or scanners had a diagnostic value.

My second perplexing finding: Not just “back” mice exist

At the beginning, I focused my research at the lumbar zone. I decided it was worthy to do a PhD study about it and, in the meantime, I started to divulge the “back mice” knowledge through Internet (web page, YouTube, Instagram, and Facebook). I created the web page with the intention to share as much scientific information as possible, hoping that this would help to move forward the “back mice” studies with the researchers and to help many patients that search the net for information.

I started an exhaustive literature review at the same time that I was exploring and treating patients. Then my “second perplexing moment” came. Reading all the scientific papers I realized that the painful nodules were not just a “lumbar” finding, they could be found in many other locations: cervical, dorsal, gluteal on the hip, or on the knee. Then we could talk about “cervical mice”, “dorsal mice”, “hip mice”, “gluteal mice”, or “knee mice”.

 Sometimes a clear nodule could be palpated on these locations, but some other times it would be palpated as an induration or a band or a subcutaneous crackling or a simple POINT. But in all the cases the subcutaneous anesthetic blockage would give a significant pain relief. The relief would last for hours or days or weeks (without a clear explanation of this by now).

My third perplexing finding: The constant locations

 Slowly, by exploring the patients, it was clear that the locations where the painful nodules, indurations, bands or points would present more severe pain complications seem to be at constant or predictable positions. It is possible to trace a body map of these locations. Even in other “medicines” as the Chinese or the Ayurveda, these “predictable locations” were described. One clear example is the “cervical mice” that is located to a constant point at 1/2 of the superior supraespinos fossa of the muscle trapezius.

My fourth perplexing finding: All the previous knowledge was lost

 As I was expanding my literature review, I realized that many medical researchers in the past studied the “intriguing nodules, bands, indurations or points of the body”. Unquestionably, they mainly used their hands to explore the patients, so they knew about their existence, and they published their studies and theories about the possible causes and treatments of these painful findings.

I published many of these “forgotten” studies in the web page. Hoping that these may help from now on to further studies. I am still perplexed that so much medical information did not reach our books, why? How could this be explained?

 My fifth perplexing finding: So many names…

As my review was going further, it was more and more clear that “the painful nodules, bands, indurations or points” in the body had been extensively studied in the past, but it also became clear that everybody gave them different names, my God! So many of them, “back mice” (diffused on the 90s) is one of the many names that the lumbar nodules have received.

That, of course, is a limitation to go further in their study “since the researchers did not find simple consensus” and knowledge just broke up into many pieces.

 My sixth perplexing finding: The “mice infestations”

Suddenly, I realized that some of my patients diagnosed with the fibromyalgia syndrome presented “lumbar back mice” that would cause them low back pain. These fibromyalgic patients experienced pain relief with the local anesthetic injection of the lumbar nodules, but also of the cervical nodules or the knee ones.

The name fibromyalgia was popularized around the 90s, before it was named in many different ways; one common denomination was fibrositis (characterized by the presence of painful nodules or points around the body). Why the presence of nodules, indurations or bands was obviated at certain moment of the recent years? Why to obviate such a crucial finding as a painful nodule? I am still perplexed about that. At certain point in history, they decided that the fibromyalgic patients just presented painful points. I considered that a crucial mistake that has probably delayed the proper study of this medical syndrome.

It seems that there are patients that just present “lumbar back mice” and chronic low back pain due to them, there are patients that just present “cervical back mice”, and cervical pain due to them, but the fibromyalgic patients seem to present a generalized affection of all the sites where “mice” have been previously described and studied. If you explore them properly, you will find painful nodules, indurations, bands and not just points. My feeling now is that somehow these patients present a “mice infestation” (multiple sites of circumscribed fibro-fatty interfacisal tissue tension that cause local pain and peripheral neuropathies).

Lets move forward all that knowledge again! 


Google positioning of

This is a poster (written in Catalan) about the SEO Google analysis of this webpage 10 months after its creation (March 2018). Our aim as a research group with is to share as much information as possible related to the back mice entity, hoping that this would lead to move forward in the study and the knowledge about it in order to help the patients. We are convinced that our web page is a useful tool for our purpose and, by organic Google positioning, we try that the web is easily reachable for medical doctors, patients and other researchers.

Introduction: We are currently investigating a medical entity (back mice), which, for several reasons, is UNKNWON to the vast majority of doctors. Many patients who suffer from this disease use GOOGLE to look for information when they see doctors have NO answers.

Objective: Our objective was to create a rigorous, scientific and free-access WEB PAGE to share information with patients, doctors and other researchers.

Methodology: In March 2018 was created. SEO (Search Engine Optimization) techniques have been used to ensure that the website has a good organic positioning with the selected “key words”. We use Google Analytics to check and analyze how many users consult the web page and we use Google Search Console to analyze organic positioning of the web. We have created a blog to discuss scientific articles. In addition, we have an email address open to the web’s users to contact us.

Results: Currently, the web page has a good organic positioning on Google. In a few months, the page already had more than 1,500 users who had consulted the page with an average duration of more than 1.5 minutes each session, thousands of impressions with more than 2,500 clicks (CTR Click through rate of 2.5%), and an average position of 9.5 for the web in Google search.

We have had contributions to the blog and emails from patients who have specifically thanked us for the information that they were given.

Discussion and conclusions: In 10 months, since its creation (March 2018), we believe that is a useful tool according to Google SEO analysis.

In the times of new technologies, the patients play a determining role in helping themselves to ensure their health.

Graphic 1: Number of users per day between April 2018 and January 2019 (10 months). A total of 3,164 users of whom 2,450 consult the web page through an ORGANIC search. An average of 2 pages per session and 2:30 minutes of average duration. The growing tendency of numbers of users can be observed.

Graphic 2: Numbers of clicks and impressions between April 2018 and January 2019. More than 2,100 clicks with thousands of impressions for keywords, for web and images (especially back mice and episacral lipoma). The average CTR is 2.6% and average position is 9.7.

Map: In blue, the distribution of total users for 10 months. In orange, the distribution of recurring users (13%) with an average duration of 4:24 minutes per session and an average of 3 pages per session.


Back mice monologue of 5 minutes (in Catalan language)

This is a monologue of 5 minutes in Catalan language. It was part of a contest called “Do you want to know what I investigate?” in November 2018 in Reus. It was organized by the Universtitat Rovira i Virgili and its aim was to promote research’s vocations among youngsters.

Title: back mice or “ratolins a l’esquena” 

This is the translation of the monologue:

Please, raise your hands those of you who know someone that has ever had “back pain”.

Many of you, as you can see… since it is considered that 2/3 of the world population suffer or will suffer “back pain” at some point… So it is a very important health problem.

There are some KNOWN causes for “back pain” such as a herniated disk or the fracture of a vertebra.

But you must know that for most of the cases, that is to say 9/10 of “back pains”, WE STILL HAVEN’T GOT A CLUE what the cause is.

We work with a HYPOTHESIS:

Maybe we know so little about this pain… because we have always researched the same parts of the human body: muscles, tendons, ligaments and bones. But we are also made of ANOTHER component…

ALL OF YOU, close your eyes and visualize a slice of “serrano ham”… There is a reddish tissue, this is the muscle tissue… but there is also a white tissue. This is the FATTY tissue, and this is what I’m studying.

The title of my thesis is “Characterization of Fibro-fatty Tissue in the Low Back”.

You may wonder: Why are you studying it, when nobody else does?

Well, anything can start with a little anecdote, and I’ll tell you mine…

One day, when my husband woke up…

Y: I’ve got back pain.

M: Oh, take ibuprofen.

Y: Won’t you see me? Or palpate me?

M: Ooops… let me see you. Is it painful here? Well, here, where it hurts you, there’s a little lump. But it WON’T be serious.

Y: Oh, it WON’T be SERIOUS. I’ve got a painful lump on my back that didn’t let me sleep and it’s NOT SERIOUS!!!!

All of a sudden, I realized… I had palpated these “little painful lumps” before… and I had the feeling that they weren’t serious… BUT I DIDN’T KNOW WHAT THEY WERE… THEY DIDN’T HAVE A NAME… they didn’t talk me about them at the Faculty of Medicine… and I couldn’t find them in my books…

BUT I was sure that other doctors must have palpated them, as I did.

So I DECIDED to do an Internet research!

And I began with Google… I didn’t have a medical word and I typed (in Spanish) “painful lumps in the back”. I found lots of forums where people said: I’ve got a painful lump in my back and my doctor doesn’t know what it is”.

Then I searched in English, pulled the string and… SURPRISINGLY I found lots of information from doctors who, throughout history and in many different parts of the world, had studied these nodules.

Now I’m studying ALL THE scientific ARTICLES and books that have been published, and I have even used Google translator to understand articles In Romanian, Italian or Serbian… I have also created a web page where I upload all the information I find and share it with other researchers…

So, what is the NAME for these nodules? Well, throughout the history of medicine they have been given MANY names… it seems that every person that discovered them gave them a name.

But the funniest name of all –the one that the latest articles use- and my favorite is the name that an American doctor gave them… back in the 90s… “back mice”.

And what do we know about these mysterious nodules?

Back mice are nodules of fat, which can be palpated in the DEEP low back, just here, where people put their hands when they have some backache. By the way, it is better to palpate them with some cream on one’s hand and the patient standing.

They have a CAPSULE, so when you palpate them, the skin feels slippery and they seem to be moving and escaping. That’s why they’re called “mice”.

They hurt when they swell. Imagine a ball under your skin that grew bigger and harder.

They can be small, the size of a pea, or big, and the size of a plum.

We have found out many things about “back mice”, but we STILL HAVE many, many questions that need to be answered:

-Why do some people have them and others don’t?

-Why are some of them painful and others are painless?

-Why CAN’T we find this knowledge in our books?

For different reasons, but maybe the fact that we doctors made the mistake to stop palpating patients a long time ago was one of them. Somehow, we used X- rays (where back mice can’t be seen) instead of our HANDS.

Now YOU do! You know more than many doctors do. You know that some little lumps that can be palpated here, in the low back zone, are called BACK MICE, and they sometimes swell and are painful… There’s STILL a lot of work to be done and many questions to be answered. If you are eager to investigate, come on! We’ll keep on studying these nodules that are so intriguing!

Marta Cañis Parera

Did Copeman really talk about “fibromyalgia” (naming it “Water retention syndrome”) in Barcelona Congress in 1951?

In 1951, Barcelona held the Second European Congress of Rheumatology in the faculty of Medicine in Barcelona.

The president was a famous Catalan doctor, professor Agustín Pedro Pons. Pere Barceló Torrent, the founder of the “Secció de reumatologia de l’Acadèmia de Ciències Mèdiques”, was also involved.

Many known rheumatologists went, such as: W. S. C. Copeman, Philip S. Hench (Nobel Prize in Medicine, 1950, from Mayo Clinic in Rochester).

Copeman presided over the Congress and he was also the opening speaker of the session about non-articular rheumatism.

Copeman’s presentation: “Water Retention Syndrome”

In the book II Congreso Europeo de Reumatología. 24-25 septiembre, 1951. Barcelona. Ponencias oficiales, the presentation that Copeman gave at the congress in 1951 is written.

It was titled “Non-articular rheumatism” and the “Water retention syndrome”, signed by Copeman and R. M. Manson.

They come from the Department of Rheumatism, from West London Hospital.

Copeman and Manson start saying that there still exist many unexplained pains that are a real medical problem and are described by the general term of “non-articular rheumatism”.

 The terms “non-articular pain” vs. “fibrositis”. Copeman’s prefers the term “non-articular rheumatism”

Sometimes the term “non-articular rheumatism” has to be ceased if a pathological process appears afterwards. But in some other cases, no other alternative appears. Then the term can be used to cover more than one type of painful syndrome.

In recent years, some authors have used the term “fibrositis” but Copeman thinks that the term leads to controversy since the term suggests a fibrotic condition.

Copeman and Manson PROPOSE a new hypothesis

They mention that NONE of current hypothesis as to the cause of “fibrositic” pain is adequate. They propose a NEW CLINICAL SYNDROME to explain the “fibrositic pain”.

They also refer to the term “panniculitis” as being erroneously used.

Current hypothesis: FIBROSITIC

Based on the work of Stockman, who studied the “rheumatic nodules” and found an inflammatory hyperplasia of the white fibrous tissue (with fibroblast but NO LEUCOCYTIC reaction). Stockman thought it could be the result of an infection but couldn’t prove it. Copeman doubts that the lesion is related to undetected focus of infection but rather to past history of rheumatic fever or strain or trauma.

The pain of the fibrous nodule can be referred quite diffusely to anywhere (with the deep neural segment). And it is sometimes erroneously attributed to the joint itself.

The fibrositic nodules are usually located at the tendinous portions or the fibrous aponeurosis of the affected muscles.

Firm pressure elicits an exquisite tenderness and may reproduce the referred pain.

 The observations related to febrile processes

Copeman (1943) observed that during the course of several febrile illnesses (influenza, measles, rubella and mumps) “trigger points” of pain could be localized. They become painless as the patient becomes apyrexial, but some remain latent and tender on pressure. They can be reactivated later by occurrence of a fever process, trauma, and temperature changes… and be the basis for “fibrositic” trouble in later life.

Kellgren Ball (1950) also points out the tendon nodules of the rheumatoid arthritis that show NOT SPECIFIC PATHOLOGICAL CHANGES.

Current hypothesis: localized muscle fiber spasm

Based on the recent electromyographic studies, it seems established that certain palpable tender “fibrositic” nodules may constitute localized muscle fiber spasm. The condition presumably results from IRRITATION of the posterior nerve roots by minor lesions in or around the spinal cord (such as developmental defects, arthritis of intervertebral joints, or a mild disc lesion). They may disappear as a result of heat, massage, or local injection of procaine.

Other hypotheses

Psychogenic rheumatism: This is the aching pain in psycho-neurotic individuals. Nodules do no refer it. It usually occurs in the tendinous insertions of certain muscle groups as the result of constant tension or spasm, secondary to their state of mental tension.

Toxaemia: Chronic muscular pain may occur as the result of infected focus such as sinusitis. During acute infection or sub-acute or chronic phase.

Others: Microtrauma (minor but repetitive trauma), severe cold and hot, unaccustomed exercise.

Fibro-fatty tissue in relation to non-articular rheumatism

In addition to the fibrous and muscular tissues, there is a third tissue, fat, also of mesodermal origin. Copeman and Mason think that fat tissue has to be considered as a cause of pain in the category of non-articular rheumatism.

Fatty tissue is widely distributed in the body. In addition to being protective, it appears to be functional, and one of its chief physiological functions is concerned with the storage of body water.

The derangement of its normal function of water-storage would lead to a PAINFUL FIBRO-FATTY TISSUE DISTENTION SYNDROME.

The term “panniculitis” has partly been used to explain this syndrome. Nevertheless, Copeman and Manson state that since no evidence of an inflammatory pathology exists (except in TRUE panniculitis), it is better to use the term “water retention” or briefly “tension syndrome”.

“Water Retention Syndrome” or “Tension Syndrome”

This is a painful condition caused by periodical swelling of the deep fatty tissue in certain well-defined sites of the body where the affected FAT LOBULES are confined by an unyielding or thickened fibrous covering.

Local tension results in pain. It is generally diagnosed as “fibrositis” in view of the lack of objective signs or sometimes as “psychogenic” rheumatism.

Onset of the “Water Retention Syndrome”

-It occurs principally in women, it can be associated to a recent increase in weight (although the victim doesn’t need to be obese).

-Its onset can be within the menopause zone or subsequent to an artificial menopause.

-Long periods of freedom from pain are not unusual.

-Sometimes it occurs only during the few days preceding the monthly menstrual period. If the patient were in menopause, at such time as when menstruation would have otherwise occurred.

-The onset of attacks is often unexpectedly acute; it usually passes off less suddenly than it occurs.

Symptoms of Copeman’s “Water Retention Syndrome”

-The general health of the patient is preserved except for the “mental depression” secondary to a prolonged attack.

-There may be disturbed sleep either by the stiffness or by pain lying on the tender area.

-A feeling of lassitude or irritability precedes some attacks.

-The patient often describes a sensation of generalized swelling of the body and limbs, in addition to that experienced as pain in certain regions (the size of the fingers can be shown to be increased, evidenced by the patient’s inability to wear their usual rings).

-Sometimes there is an increase in body weight.

Sites of pain:

-Although the patient described severe pains as diffuse, examination would reveal it to be situated in certain well-defined areas in which the deep fatty tissue is confined by an indistinguishable fibrous fascia. These sites have been shown in a diagram in previous studies.

-The dorsal and the knee fat-pads are usually the most commonly implicated.

-If the sacrum fat-pad is involved, then it may be visible from inspection.

-The skin shows a “peau d’orange” appearance.

-On palpation there are painful nodules”.

-There can be “trigger points” situated in the fat-pads.

Copeman and Manson’s clinical investigations with patients with “fibrositic pain”


They did 3 types of experiments to try to force or to reduce the body water retention.

First experiments: Copeman and Manson tried to do experiments by weight reduction and diuretics, without any conclusive result to pain relief.

Second experiments: Later, they tried to induce an artificially “water retention syndrome” with and hormone deoxycortone to induce an attack, which also failed. They explained 5 cases. And they showed the fluid balance, body weight and pain subjective assessment in the clinical charts.

Third experiments: By chance, they observed a patient who was given cortisone for osteoarthritis; they observed the knee fat pads increased of size. Then they experimented on two cases. They administrated single large intramuscular cortisone dose that exacerbated the pains of the tension syndrome in both patients. Then they experimented by causing INTRACELULAR DEHYDRATATION in two patients by injection of intravenous hypertonic saline, which reduced the pain temporarily. They finally hypothesized cortisone may increase an increased volume in intracellular fluid, and then increase the water retention syndrome.

One of the cases was Case 1. Woman, 24 years old. Severe lumbar backache for six years. Pain all over the lumbar region fluctuating in severity but always present. Pain did not radiate to legs. No lumbar spine lesion was found. Four years before, an iliac fatty hernia was removed, which relieved her pain. However, pain recurred more generally and she was admitted to hospital. On examination MULTIPLE EXQUISITELY TENDER NODULES could be felt over both iliac crest. X-ray revealed no changes. The experiments they did on her didn’t have any effect on her pain.

Published in April 2018 By Marta Cañis Parera  ORCID iD icon


  • Book II Congreso Europeo de Reumatología. 24-25 septiembre 1951. Barcelona. Ponencias oficiales. Editorial Publicaciones Médicas José Janés Editor. Cuarta ponencia: Reumatismo no articular y síndrome de retención de agua. W. S. C. Copeman. Páginas 209-228
  • Copeman W. S. Aetiology of the Fibrositic Nodule. Br Med J. 1943 Aug 28; 2(4312): 263-4. PubMed PMID: 20785002; PubMed Central PMCID: PMC2284845.
  • Copeman W. S. C. Fibro-fatty Tissue and its Relation to “Rheumatic” SyndromesBritish Medical Journal. 1949; 2(4620): 191-197.

The project

I am Marta Cañis Parera. I am a medical doctor from nearby Barcelona. On February 2018, I started my Ph.D. studies about “fatty tissue and low back pain” in the Universitat Rovira i Virgili from Reus, Spain.

As part of my Ph.D. studies I am doing a bibliographic review about fatty tissue as a cause of low back pain. Within my thesis project I am under the construction of this web page called, where I plan to share this bibliographic review (in 4 main chapters) and write a blog with my personal views  at the same time.

The aim of the project is to share the information about this entity that still seems to be under-recognized by many doctors nowadays, and to make it a useful tool for me to share information with other researchers or people who may have a special interest in it.